90% of therapeutic programs in clinical trials fail. Human genetic variation offers "natural experiments" that can inform successful therapeutic strategies with drug targets backed by human genetics 2-3 times more likely to succeed in the clinic. 23andMe has a dataset about ten times larger than current public cohorts, with approximately 15 million genotyped individuals, 80% of whom consent to research. In this session, you'll hear from Xin Wang, Ph.D., senior research scientist in statistical genetics at 23andMe as she explores how the scale of genetic data and improved methods to link genetic associations to causal genes impact clinical success predictions.