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Gencove’s low-pass sequencing platform is setting the new standard for high-throughput genomics research and diagnostics applications across species.
Get access to whole genome information at the cost of genotyping arrays.
Over 99% accurate genome-wide information for every sample
Similar or lower cost than existing assays
Ready for enterprise and large-scale production applications
Easy to set up, customize and update
Easy to combine with target assays
Scientific expertise and support

High power for discovery
High imputation quality from low-pass sequencing enables high-powered genome-wide association and fine-mapping studies
More possibilities for downstream analysis
Low-pass sequencing allows for highly accurate risk score calculations, ancestry analysis, CNV calling, and more
Upgrade any targeted assays
Low-pass sequencing can be combined in a single workflow with other assays like targeted panels or exomes

Increased power for prediction
More data to increase accuracy of genomic prediction
Easy and cost-efficient set up
Easy to set up new species and customize to your specific populations or lines
One assay replacing all future high and low density assays
With genome-wide information, updates to new sets of variants can be completely software-based
More power for discovery
High imputation quality from low-pass sequencing enables high-powered genome-wide association and fine-mapping studies

More power for discovery
High imputation quality from low-pass sequencing enables high-powered genome-wide association and fine-mapping studies
Easy to combine with targeted assays
Low-pass sequencing combined with customizable targeted panels enables diagnostic-quality variant calls in a cost-effective manner
Cost-effective setup
Easy to set up new species and customize to breeds of interest
Prof. Eran Segal
Principal Investigator at Weizmann Institute of Science
Gencove’s imputation and analysis platform returns over 99% accurate variant calls for every sample.
The components of a low-pass sequencing assay involve multiplexing large numbers of DNA samples in a single lane or run of a sequencer, sequencing them at a very low coverage (frequently starting at 0.4x), then performing genotype imputation to make genotype calls at all sites known to be polymorphic in the population.
Components

Gencove’s platform is scalable and fast to set up for your organization’s high-throughput genotyping and analysis programs.
Start with ready-to-run or custom pipelines
Choose an existing pipeline or work with Gencove’s scientists to optimize the platform for your application
Select the appropriate deployment model that fits your needs
End-to-end
From biological sample to data through our sequencing partners that have already integrated with Gencove
In-house
Set up the low-pass lab workflow in your lab and seamlessly use the Gencove imputation and analysis SaaS
SaaS-only
Integrate Gencove directly with your existing systems or greenfield deployments
Gencove is scalable, secure, and flexible. It's an end-to-end solution that enables your team to focus on valuable discoveries instead of the mechanics of large-scale genomic data analysis.
Cloud-scale
Gencove is cloud-native, meaning end-to-end analysis is done in the cloud
Security
Rest assured Gencove is using industry-accepted best practices and frameworks
Compliance
Gencove is HIPAA compliant and aligns itself with ISO27001 and SOC2
Speed
Fast analytics together with lightning-fast uploads and downloads through CLI tools
Collaboration
Share projects with colleagues across your organization
Integration
Integrate directly with our API for production-ready workloads
Customization
Private configurations and reference panels for custom populations can be made available
Support
If you run into a snag, our team is there to help quickly and efficiently!
Why Gencove?

Learn how Gencove helped Neogen across its organization
weeks to set up a custom poultry imputation panel
samples processed in a day
genetic variants called at 99% accuracy