Whole genome discovery at the cost of genotyping
Gencove's low-pass sequencing platform is the most efficient solution for genomic discovery. Start sequencing and increase the power and scale of your genomic projects.
Starting at $50 per sample
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Our Technology
Gencove’s platform delivers the power of sequencing in a cost-efficient manner. Optimized library preparation and advanced imputation algorithms enable us to extract more information from every sequencing read.
Averaging across all known variation, low-pass sequencing outperforms genotyping arrays at common and rare variation. Since it does not have ascertainment biases, it’s the optimal technology for use across populations. At scale we can also identify new genetic variants that have never been seen before.
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Library preparation
Our library preparation method was developed specifically for low-pass sequencing. It is automated, resource efficient, and requires low amounts of input DNA. An optional capture step allows the addition of targeted genomic regions at high coverage.
Sequencing
We perform low-pass shotgun sequencing at 0.4 to 1x coverage using the latest Illumina technology. This results in an average of 50 times more measurements per genome than genotyping technologies.
Imputation & data analysis
We developed imputation algorithms for sequencing data to call variants across the whole genome with high accuracy (average imputation r2 over 0.9). Additionally, our standard data analysis includes ancestry and microbiome profiling of every sample.
Solutions
We work with researchers in biotech, pharma, biobanks, and academia, and we also power direct-to-consumer genomic tests and products.
Common use cases
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Genetic association studies
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Population genetics and ancestry profiling
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Disease gene panels and polygenic risk profiling
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Agricultural and animal genomics
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Microbiome profiling
Select the coverage level that best fits your needs
We offer our low-pass sequencing technology as an end-to-end solution, from sample preparation to analysis-ready data.
What our solutions include:
COVERAGE
IMPUTATION OUTPERFORMS
AVERAGE MARKERS
DELIVERABLES
Core
$50Move from genotyping arrays to sequencing
0.4X
Illumina GSA
30,000,000*
Data files: Imputed VCF file**, BAM file
Other results: Ancestry analysis, Microbiome, Novel variant discovery***
Discovery
$90Increase your power to discover new genetic variation
1X
Affymetrix Biobank
Illumina 2.5M
60,000,000*
Data files: Imputed VCF file**, BAM file
Other results: Ancestry analysis, Microbiome, Novel variant discovery***
Plus Capture
Customized solutionCore or Discovery + targeted exon or SNP variant calls
Add custom content to target specific regions and/or variants while retaining competitive pricing.
+ targeted regions
Price based on a minimum batch of 94 samples
* Low-pass sequencing provides measurements at random sites in the genome that are covered by at least one sequencing read
** Imputation is based on the 1000 Genomes Phase 3 or HRC
*** Available for large cohorts
Need more?
If you have questions or custom requirements reach out to us
Contact UsWe regularly process genomic DNA, saliva, and blood samples. Let us know if your samples are from other sources and we'll work with you to get them processed. Saliva samples can be collected using most commercial saliva collection kits or saliva collection swabs. Genomic DNA can be provided in standard 96-well plates or microcentrifuge tubes.
See here for detailed sample submission guidelines.
Results are returned within 6-8 weeks from the time samples arrive in our lab. Let us know if you have special requirements for turnaround time and we'll work with you to make sure your samples are done on time!
All customers get access to our data management website (https://app.gencove.com), where sample status can be tracked all the way from sample acceptance by our lab to delivery-ready data. In addition to the website, users can monitor sample status and automate data delivery by integrating with our REST API (https://docs.gencove.com).
Data can be accessed via the Gencove data management website or REST API. For downloading data in bulk, we recommend using the API or our command-line tool (https://docs.gencove.com/main/#the-gencove-cli).
Absolutely! You can use the API to track sample status and automate data delivery. Check out the docs here: https://docs.gencove.com
We regularly work with multiple sample collection kit manufacturers and logistics centers. Contact us and we can get you up and running.
We always use the latest Illumina sequencing machines. Depending on the specifics of your project, we'll use the NovaSeq, HiSeq X, or NextSeq.
Use Cases
Baker Institute - Genomic risk in celiac disease
Baker Institute is developing a genomic risk score that can help predict risk of celiac disease that is yet to manifest itself. Gencove’s low-pass sequencing will be used to establish the validity and utility of genomic risk approaches for identifying individuals at high risk.
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University of Michigan - PSID
The Panel Study of Income Dynamics (PSID) is the world’s longest running household panel survey. Gencove’s low-pass sequencing is being used to add genomic information to the study with the aim of fully understanding the interplay of genetics and environment over the life course of the participants.
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Broad Institute - Darwin’s Dogs
Darwin's Dogs is a crowd-sourced genomics project studying how the dog genome has changed through history. Using low-pass sequencing, researchers are studying how genetics shapes behaviour, and psychiatric and neurological diseases in both dogs and people.
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Stanford University - Conservation Genomics
The program is developing tools for the next generation of conservation scientists. By using low-pass genome sequencing, they are investigating the population genomics of endangered mammals like rhinos, tigers, and lions. In addition, they are sequencing sanctuary and captive animals in order to understand how the illegal wildlife trade impacts wild populations and their cosmopolitan trade routes.
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University of Utah - Gene discovery in diabetes
Researchers are applying a novel and innovative approach to accelerate gene discovery in diabetic kidney disease that integrates big data from the Utah Population Database. Deep whole-genome sequencing on select members of these pedigrees is being combined with Gencove's low-pass sequencing data on additional individuals from high-risk families.
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About Us
We are a group of scientists, engineers, and entrepreneurs who are building a future where genome sequencing is accessible and interpretable.
Joe Pickrell
CEO & Co-founder
Joe is a statistical geneticist who has published scientific papers in the most selective scientific journals like Nature, Science, Nature Genetics, and PNAS. Prior to founding Gencove, he was a professor at New York Genome Center and Columbia University, and he holds a PhD in Human Genetics from the University of Chicago.
Kaja Wasik
CSO & Co-founder
Kaja develops new molecular biology methods and oversees the laboratory at Gencove. Prior to founding Gencove, she received her Ph.D. in molecular biology from Cold Spring Harbor Laboratory, completed postdoctoral training at New York Genome Center, and worked in the biotechnology startup space.
Tomaz Berisa
CTO & Co-founder
Tomaz spends his time at the intersection of genomics and computer science, and is responsible for tech at Gencove. Prior to founding Gencove, he was a data scientist at the New York Genome Center. He holds a PhD in Electrical Engineering from the University of Zagreb.