Human genomics events

Understanding the genetic causes for variability in chromatin accessibility can shed light on the molecular mechanisms through which genetic variants may affect complex traits. Join us to hear Brandon Wenz from University of Pennsylvania share his latest research into chromatin accessibility quantitative trait loci (caQTLs) and their role in genetic regulation and complex traits. This study analyzed over 10,000 samples from 1,454 individuals across 600 studies, identifying 23,381 caQTLs. We'll discuss how joint genotyping, chromatin accessibility peak calling, and context-specific caQTL identification can reveal the genetic mechanisms that influence gene expression and contribute to disease, highlighting the potential of caQTL analyses in ungenotyped samples.

Thursday, October 3rd, 12:00 PM Eastern

Register here

Join Josh Setton from the Gencove team at the event, where he’ll be available to discuss how we’ve optimized every stage of data generation, both upstream and downstream. Learn how our modular, affordable, and scalable solutions are transforming genomic data generation, analysis, and management for biobanks and health systems. We’d love to connect with you—reach out to schedule a meeting!

90% of therapeutic programs in clinical trials fail. Human genetic variation offers "natural experiments" that can inform successful therapeutic strategies with drug targets backed by human genetics 2-3 times more likely to succeed in the clinic. 23andMe has a dataset about ten times larger than current public cohorts, with approximately 15 million genotyped individuals, 80% of whom consent to research. In this session, you'll hear from Xin Wang, Ph.D., senior research scientist in statistical genetics at 23andMe as she explores how the scale of genetic data and improved methods to link genetic associations to causal genes impact clinical success predictions.

The Gencove team will be at The Festival of Genomics & Biodata in Boston this year. Get in touch to meet us there and learn how Gencove is working with life sciences companies to accelerate R&D efforts across the drug development process

The Gencove team will be at BIO in San Diego this year. Get in touch to meet us there and learn how Gencove is working with life sciences companies to accelerate R&D efforts across the drug development process

Coupling rich electronic health record data with the ability to sequence patients of interest is key to the identification of molecular signatures of specific populations and their application to drug discovery. In our latest webinar, Olivia Sabik from Valo Health shares how their collaboration with Kahn-Sagol-Maccabi (KSM), Maccabi Healthcare Services' Research and Innovation Center, offers an unparalleled opportunity to identify patient cohorts using deep longitudinal data. She discusses how the unique population history of these cohorts provides an opportunity for groundbreaking discoveries and how Valo Health is leveraging the Gencove platform to accelerate this discovery.

Gencove CEO & co-founder, Joe Pickrell is presenting at this years Bio-IT World Conference & Expo on Monday April 15th at 9:10am. Join us to hear how Gencove is working with life sciences companies to accelerate R&D efforts across the drug development process

In this session, Mary T. Yohannes and Zan Koenig from the Broad Institute discuss their recent work on the harmonization of the Human Genome Diversity Project (HGDP) and the 1000 Genomes Project (1kGP) datasets. They highlight how this combination has led to significant advancements in understanding global genetic diversity, how it can benefit the study of underrepresented populations, and the cataloging of millions of new genetic variants. Additionally, Jeremy Li, Director of Data Science at Gencove, presents an analysis of the combined HGDP and 1kGP reference panel and how it can enhance the accuracy and efficiency of low-pass whole genome imputation.

See you at AGBT 2024! Gencove's Dr Caitlin Stewart is presenting "A comparison between low-cost library preparation kits for low-coverage sequencing" on Tuesday February 6th, at 1:30pm. Get in touch to meet with Gencove CEO & co-founder, Joe Pickrell in Orlando.

We're hosting a session on From samples to solutions: strategies for data generation, analysis, and management on Thursday November 2nd, 3:30pm-4:30pm in Room 144B. Join us for an exploration of real-world applications and success stories, as we share how Gencove's end-to-end platform is transforming the landscape of genomic data generation, analysis, and management.

Genome-Wide-Association Studies (GWAS) require large-scale cohorts with both phenotype and genetic sequencing data, which has limited studied phenotypes. In this session, Zachary Levine from the Weizmann Institute of Science will delve into the outcomes of their GWAS and PRS-PheWAS involving 727 clinical phenotypes and 4,045 molecular features from the Human Phenotype Project. Join us to learn more about previously unlinked clinical traits and the study's utilization of low-pass whole genome sequencing, which has brought forth fresh insights into the intricate genetic architecture governing complex human phenotypes

Learn how Barbara Rae-Venter uses a suite of genetic genealogy tools in her pioneering work reviving cold cases showcased in her new book, I Know Who You Are.