Understanding the genetic causes for variability in chromatin accessibility can shed light on the molecular mechanisms through which genetic variants may affect complex traits. Join us to hear Brandon Wenz from University of Pennsylvania share his latest research into chromatin accessibility quantitative trait loci (caQTLs) and their role in genetic regulation and complex traits. This study analyzed over 10,000 samples from 1,454 individuals across 600 studies, identifying 23,381 caQTLs. We'll discuss how joint genotyping, chromatin accessibility peak calling, and context-specific caQTL identification can reveal the genetic mechanisms that influence gene expression and contribute to disease, highlighting the potential of caQTL analyses in ungenotyped samples.
Thursday, October 3rd, 12:00 PM Eastern
