In this session, Mary T. Yohannes and Zan Koenig from the Broad Institute discuss their recent work on the harmonization of the Human Genome Diversity Project (HGDP) and the 1000 Genomes Project (1kGP) datasets. They highlight how this combination has led to significant advancements in understanding global genetic diversity, how it can benefit the study of underrepresented populations, and the cataloging of millions of new genetic variants. Additionally, Jeremy Li, Director of Data Science at Gencove, presents an analysis of the combined HGDP and 1kGP reference panel and how it can enhance the accuracy and efficiency of low-pass whole genome imputation.